Once again, I’ll venture a few predictions.
1) The enemy’s attempt to destroy (or to change in a way constituting de facto destruction) Social Security and Medicare will fail, for the same reason as in 2005 — some Republicans will vote against doing so, knowing that the huge unpopularity of such a move would destroy their re-election hopes. Remember, if all Senate Democrats stick together they need only three Republicans to block something, even without the filibuster.
2) Culturally the US will continue becoming more liberal and less religious despite Republican efforts to reverse progress — recall how things like secularism and acceptance of gays and gay marriage kept advancing even during the Bush years.
3) The Paris climate agreement will be effective even if Trump repudiates it.